Adoptive T‐cell immunotherapy for ganciclovir‐resistant CMV disease after lung transplantation. Issue 3 (27th March 2015)

• Record Type: Journal Article
• Authors: Holmes‐Liew, Chien‐Li; Holmes, Mark; Beagley, Leone; Hopkins, Peter; Chambers, Daniel; Smith, Corey; Khanna, Rajiv
• Is Part Of: Clinical & translational immunology. Volume 4:Issue 3 (2015)
• Page Start: n/a
• Page End: n/a
• Publication Date: 2015-03-27
• Subjects: Immunologic diseases -- Periodicals; Immunology -- Periodicals; Clinical medicine -- Periodicals; Immune System Diseases -- therapy; Immunotherapy; Immunologic Factors -- therapeutic use; Translational Medical Research; Molecular Targeted Therapy; Clinical medicine; Immunologic diseases; Immunology; Periodicals; Periodicals; Fulltext; Internet Resources; Periodicals; 616.079
• DOI: 10.1038/cti.2015.5
• Languages: English
• ISSNs: 2050-0068

Abstract

Abstract : Infections with cytomegalovirus (CMV) can induce severe complications after solid organ transplantation (SOT). The prognosis for ganciclovir‐resistant CMV infection and disease is particularly poor. Whereas adoptive transfer of CMV‐specific T cells has emerged as a powerful tool in hematopoietic stem cell transplant patients, its translation into the SOT setting remains a significant challenge as underlying immunosuppression inhibits the virus‐specific T‐cell response in vivo . Here, we demonstrate successful expansion and adoptive transfer of autologous CMV‐specific T cells from a seronegative recipient of a seropositive lung allograft with ganciclovir‐resistant CMV disease, resulting in the long‐term reconstitution of protective anti‐viral immunity, CMV infection, disease‐free survival and no allograft rejection.