Three new oxylipins from an Okinawan marine sponge Plakortis sp. Issue 11 (11th March 2015)

• Record Type: Journal Article
• Authors: Tanaka, Naonobu; Asai, Miki; Kusama, Taishi; Fromont, Jane; Kobayashi, Jun'ichi
• Is Part Of: Tetrahedron letters. Volume 56:Issue 11(2015)
• Page Start: 1388
• Page End: 1391
• Publication Date: 2015-03-11
• Subjects: Marine sponge -- Plakortis sp. -- Oxylipin -- Manzamenone P; Chemistry, Organic -- Periodicals; 547.005
• DOI: 10.1016/j.tetlet.2015.01.137
• Languages: English
• ISSNs: 0040-4039

Abstract

Graphical abstract: Abstract: Three new oxylipins, manzamenone P (1 ), 6′- O -methylmanzamenone K (2 ), and 6′- O -ethylmanzamenone K (3 ), were isolated from an Okinawan marine sponge Plakortis sp. Manzamenone P (1 ) is a unique oxylipin possessing two long acyl chains and a novel core unit consisting of spiro-bonded cyclohexanone and β-keto-γ-lactone rings. The structures of1 –3 were elucidated on the basis of spectroscopic evidences including 2D NMR and FABMS/MS spectra as well as a comparison of DFT calculated NMR data with those experimental data.