Intermolecular coupling of 2-iodoanilides with benzoxazoles: synthesis of N-(2-Benzoxazol-2-ylphenyl)benzamides via C–H activation. Issue 11 (11th March 2015)

• Record Type: Journal Article
• Authors: Sasmal, Swarnendu; Sen, Indira; Hall, Roger G.; Pal, Sitaram
• Is Part Of: Tetrahedron letters. Volume 56:Issue 11(2015)
• Page Start: 1374
• Page End: 1377
• Publication Date: 2015-03-11
• Subjects: Benzoxazole -- C–H activation -- Intermolecular coupling -- o-Iodoanilides; Chemistry, Organic -- Periodicals; 547.005
• DOI: 10.1016/j.tetlet.2015.01.150
• Languages: English
• ISSNs: 0040-4039

Abstract

Graphical abstract: Abstract: Using CuI/xantphos/Pd(OAc)2 catalytic system, the intermolecular C–C cross coupling between benzoxazoles and ortho -haloanilides has been developed in moderate to good yields. The procedure tolerates a series of functional groups on benzoxazole, such as ester, chloro, methyl, and methoxy groups. This divergent approach provides access to various N -(2-Benzoxazol-2-ylphenyl)amides.