Microwave-assisted synthesis of xanthones promoted by ytterbium triflate. Issue 6 (4th February 2015)

• Record Type: Journal Article
• Authors: Genovese, Salvatore; Fiorito, Serena; Specchiulli, Maria Carmela; Taddeo, Vito Alessandro; Epifano, Francesco
• Is Part Of: Tetrahedron letters. Volume 56:Issue 6(2015)
• Page Start: 847
• Page End: 850
• Publication Date: 2015-02-04
• Subjects: Lanthanides -- Lewis acids -- Microwave synthesis -- Ytterbium triflate -- Xanthones; Chemistry, Organic -- Periodicals; 547.005
• DOI: 10.1016/j.tetlet.2014.12.123
• Languages: English
• ISSNs: 0040-4039

Abstract

Graphical abstract: Abstract: Xanthones represent a class of naturally occurring compounds with valuable and promising reported pharmacological activities. One of the main disadvantages in the use of such products is related to the difficulties in their chemical synthesis. In this Letter a new and improved method for the chemical synthesis of xanthones is described. The title compounds have been synthesized in good yields under microwave irradiation from substituted 2-hydroxybenzoic acids and phenols in the presence of Yb(OTf)3 hydrate as the catalyst.