Oxidative coupling of formamides with β-dicarbonyl compounds and the synthesis of 2-aminobenzothiazole using Cu(II)-functionalized Fe3O4 nanoparticles. Issue 6 (4th February 2015)

• Record Type: Journal Article
• Authors: Azizi, Kobra; Karimi, Meghdad; Heydari, Akbar
• Is Part Of: Tetrahedron letters. Volume 56:Issue 6(2015)
• Page Start: 812
• Page End: 816
• Publication Date: 2015-02-04
• Subjects: Enol carbamates -- Dimethylformamide -- 2-Aminobenzothiazoles -- Oxidation -- Magnetic nanoparticles; Chemistry, Organic -- Periodicals; 547.005
• DOI: 10.1016/j.tetlet.2014.12.110
• Languages: English
• ISSNs: 0040-4039

Abstract

Graphical abstract: Abstract: The Fe3 O4 @EDTA–Cu(II) nanoparticles catalyzed oxidative coupling of formamides with β-dicarbonyl compounds is developed using tert -butyl hydroperoxide as an oxidant. In general, the enol carbamates are synthesized in excellent yields (up to 92%) under the optimized reaction conditions. Fe3 O4 @EDTA–Cu(II) has the advantage of being magnetically recoverable. Also, we have established a highly efficient Fe3 O4 @EDTA–Cu(II)-catalyzed tandem reaction of 2-iodoanilines with isothiocyanates for the synthesis of 2-aminobenzothiazoles.