A biomimetic method to synthesise indolo[3, 2-a]carbazoles. Issue 2 (8th January 2015)

• Record Type: Journal Article
• Authors: Liang, Li-na; Fan, Tian-yun; Huang, Tao; Yan, Chen; Xu, Mei; Liu, Sheng
• Is Part Of: Tetrahedron letters. Volume 56:Issue 2(2015)
• Page Start: 434
• Page End: 436
• Publication Date: 2015-01-08
• Subjects: Indolo[3, 2-a]carbazoles -- Biomimetic synthesis -- Transamination -- Aromatic cyclisation; Chemistry, Organic -- Periodicals; 547.005
• DOI: 10.1016/j.tetlet.2014.11.136
• Languages: English
• ISSNs: 0040-4039

Abstract

Graphical abstract: Abstract: A simple and biomimetic synthetic strategy for indolo[3, 2- a ]carbazoles has been developed. Our approach involved the efficient conversion of 2-(3′-indolyl)tryptophan derivatives into the corresponding α-keto esters and the subsequent aromatic cyclisation of these intermediates to construct the characteristic heteroaryl-condensed carbazole core.