3-epi-Waol A and Waol C: polyketide-derived γ-lactones isolated from the endophytic fungus Libertella blepharis F2644. Issue 1 (1st January 2015)

• Record Type: Journal Article
• Authors: Adames, Itzel; Ortega, Humberto E.; Asai, Yumi; Kato, Masaki; Nagaoka, Kazuya; TenDyke, Karen; Yongchun Shen, Young; Cubilla-Ríos, Luis
• Is Part Of: Tetrahedron letters. Volume 56:Issue 1(2015)
• Page Start: 252
• Page End: 255
• Publication Date: 2015-01-01
• Subjects: γ-Lactones -- Libertella blepharis -- Olyra latifolia -- Biological activities; Chemistry, Organic -- Periodicals; 547.005
• DOI: 10.1016/j.tetlet.2014.11.081
• Languages: English
• ISSNs: 0040-4039

Abstract

Graphical abstract: Abstract: Two new γ-lactones, 3- epi -Waol A (1 ), and Waol C (2 ) were isolated, together with three known compounds [1-hydroxy-6-methyl-8-hydroxymethylxanthone, pestacin, and isopestacin], from the solid culture of the endophytic fungus Libertella blepharis that had been isolated from the mature leaf of Olyra latifolia, collected in the province of Colon, Republic of Panama. Elucidation of their structure was accomplished using 1D and 2D NMR spectroscopy in combination with IR spectroscopic and MS data. 3- epi -Waol A (1 ) showed a growth inhibition with IC50 values of 22.71 μM against the parasite Trypanosoma cruzi ; and 22.46, 6.20, and 1.0 μM against MCF-7, HCT116, and H460 cancer cell lines, respectively.