2-Pyridyl glycoside: an alternative glycosyl donor in preactivation protocol. Issue 1 (1st January 2015)

• Record Type: Journal Article
• Authors: Xiong, De-Cai; Yang, An-Qi; Yu, Yang; Ye, Xin-Shan
• Is Part Of: Tetrahedron letters. Volume 56:Issue 1(2015)
• Page Start: 211
• Page End: 214
• Publication Date: 2015-01-01
• Subjects: 2-Pyridyl glycoside -- Trifluoromethanesulfonic anhydride -- Preactivation -- Glycosylation -- One-pot synthesis; Chemistry, Organic -- Periodicals; 547.005
• DOI: 10.1016/j.tetlet.2014.11.066
• Languages: English
• ISSNs: 0040-4039

Abstract

Graphical abstract: Abstract: 2-Pyridyl glycosides have been identified to be powerful glycosyl donors for the preactivation-based oligosaccharide synthesis. By using stoichiometric amount of Tf2 O, the 2-pyridyl glycosides were pre-activated, which subsequently underwent glycosylation reactions smoothly to produce the coupled products in high yields. Furthermore, the 2-pyridyl glycosides were applied to the efficient oligosaccharide assembly by the preactivation-based one-pot oligosaccharide synthesis protocol.