Oxalic/malonic acids as carbon building blocks for benzazole, quinazoline and quinazolinone synthesis. Issue 8 (2nd February 2018)

• Record Type: Journal Article
• Authors: Sharma, Saurabh; Bhattacherjee, Dhananjay; Das, Pralay
• Is Part Of: Organic & biomolecular chemistry. Volume 16:Issue 8(2018)
• Page Start: 1337
• Page End: 1342
• Publication Date: 2018-02-02
• Subjects: Chemistry, Organic -- Periodicals; Bioorganic chemistry -- Periodicals; Chemistry, Physical organic -- Periodicals; 547
• DOI: 10.1039/c7ob03064a
• Languages: English
• ISSNs: 1477-0520

Abstract

Abstract : Oxalic/malonic acids as CH/C2 H3 carbon building blocks for the synthesis of 2-substituted and un-substituted benzazoles, quinazolines and quinazolinones. Abstract : An oxidant, base and metal free methodology has been developed for the synthesis of various 2-substituted and non-substituted benzazoles, quinazolines and quinazolinones using oxalic/malonic acids as an in situ carbon source. This methodology is applicable for a wide range of substituted o -phenylenediamine, o -aminothiophenol, o -aminophenol and o -aminobenzamide containing various functional groups and provides good to excellent yields of the corresponding product. Furthermore an easy workup procedure, high yield and easy isolation of products are key features of this methodology. The developed protocol is also applicable for the gram scale synthesis of benzimidazoles.