Engineering functional inorganic–organic hybrid systems: advances in siRNA therapeutics. (8th February 2018)

• Record Type: Journal Article
• Authors: Shen, Jianliang; Zhang, Wei; Qi, Ruogu; Mao, Zong-Wan; Shen, Haifa
• Is Part Of: Chemical Society reviews. Volume 47:Number 6(2018)
• Page Start: 1969
• Page End: 1995
• Publication Date: 2018-02-08
• Subjects: Chemistry -- Periodicals; 540
• DOI: 10.1039/c7cs00479f
• Languages: English
• ISSNs: 0306-0012

Abstract

Abstract : Engineering functional inorganic–organic hybrid vectors for siRNA delivery systems as a promising approach to overcome many physiological and biological obstacles, which greatly paves the way for a successful, safe and efficient platform in clinical applications. Abstract : Cancer treatment still faces a lot of obstacles such as tumor heterogeneity, drug resistance and systemic toxicities. Beyond the traditional treatment modalities, exploitation of RNA interference (RNAi) as an emerging approach has immense potential for the treatment of various gene-caused diseases including cancer. The last decade has witnessed enormous research and achievements focused on RNAi biotechnology. However, delivery of small interference RNA (siRNA) remains a key challenge in the development of clinical RNAi therapeutics. Indeed, functional nanomaterials play an important role in siRNA delivery, which could overcome a wide range of sequential physiological and biological obstacles. Nanomaterial-formulated siRNA systems have potential applications in protection of siRNA from degradation, improving the accumulation in the target tissues, enhancing the siRNA therapy and reducing the side effects. In this review, we explore and summarize the role of functional inorganic–organic hybrid systems involved in the siRNA therapeutic advancements. Additionally, we gather the surface engineering strategies of hybrid systems to optimize for siRNA delivery. Major progress in the field of inorganic–organic hybrid platforms including metallic/non-metallic cores modified with organic shells or further fabrication as the vectors for siRNA delivery is discussed to give credit to the interdisciplinary cooperation between chemistry, pharmacy, biology and medicine.