Accelerated multi-reagent copper catalysed coupling reactions in micro droplets and thin films. Issue 2 (13th February 2018)

• Record Type: Journal Article
• Authors: Iyer, Kiran; Yi, Jing; Bogdan, Andrew; Talaty, Nari; Djuric, Stevan W.; Cooks, R. Graham
• Is Part Of: Reaction chemistry & engineering. Volume 3:Issue 2(2018)
• Page Start: 206
• Page End: 209
• Publication Date: 2018-02-13
• Subjects: Reaction mechanisms (Chemistry) -- Periodicals; Chemical engineering -- Periodicals; Chemical engineering; Reaction mechanisms (Chemistry); Periodicals; 547.705
• DOI: 10.1039/c8re00002f
• Languages: English
• ISSNs: 2058-9883

Abstract

Abstract : Electrospray (ES) and paper spray (PS) mass spectrometry were used to create confined liquid volumes in which accelerated air and water sensitive, heterogeneous, copper catalysed C–O and C–N coupling reactions occur. Abstract : Electrospray (ES) and paper spray (PS) mass spectrometry were used to create confined liquid volumes in which accelerated air and water sensitive, heterogeneous, copper catalysed C–O and C–N coupling reactions occur. Significant reaction acceleration was observed compared to the bulk reaction which required elevated temperatures and time for completion. Macroscopic amounts of product (mg scale) were prepared using offline ES within minutes. The trends in reactivity observed for several reagents matched those of the bulk reactions making droplet accelerated reactions good mimics of the bulk chemistry.