Facile preparation of versatile gadolinium-chelated protein nanocomposite for T1 magnetic resonance imaging-guided photodynamic and photothermal synergetic therapy. Issue 11 (2nd March 2018)

• Record Type: Journal Article
• Authors: Liu, Pei; Zheng, Hongyi; Yang, Zhe; Ba, Li; Zhu, Wei; Lin, Leping; Xiong, Yuxuan; Xu, Zushun; Ren, Jinghua
• Is Part Of: Journal of materials chemistry. Volume 6:Issue 11(2018)
• Page Start: 1688
• Page End: 1698
• Publication Date: 2018-03-02
• Subjects: Materials -- Periodicals; Chemistry, Analytic -- Periodicals; Biomedical materials -- Research -- Periodicals; 543.0284
• DOI: 10.1039/c8tb00148k
• Languages: English
• ISSNs: 2050-750X

Abstract

Abstract : Imaging-guided photodynamic/photothermal (PDT/PTT) synergetic therapy is important in more precise and efficient cancer treatment. Abstract : Imaging-guided photodynamic/photothermal (PDT/PTT) synergetic therapy is important in more precise and efficient cancer treatment. Herein, gadolinium-chelated porphyrin–protein composite based on gold nanorods (GNRs@BPP-Gd) was synthesized through a straightforward and environmentally friendly method. Based on the high longitudinal relaxivity (9.544 mM −1 s −1 ), GNRs@BPP-Gd can serve as a decent T 1 -weighted magnetic resonance imaging (MRI) probe to steer treatment. A relevant cellular uptake assay showed that GNRs@BPP-Gd could be internalized into cancer cells effectively with negligible cytotoxicity. Furthermore, MRI-guided PDT/PTT studies in vivo indicated that GNRs@BPP-Gd could efficiently take effect after intravenous injection, leading to almost complete ablation at the tumor site. A single treatment was conducted for comparison with the combined treatment, indicating that synergetic therapy greatly enhanced the anti-tumor effect.