Tailored trisubstituted chiral CpxRhIII catalysts for kinetic resolutions of phosphinic amides. Issue 11 (23rd February 2018)

• Record Type: Journal Article
• Authors: Sun, Y.; Cramer, N.
• Is Part Of: Chemical science. Volume 9:Issue 11(2018)
• Page Start: 2981
• Page End: 2985
• Publication Date: 2018-02-23
• Subjects: Chemistry -- Periodicals; 540.5
• DOI: 10.1039/c7sc05411d
• Languages: English
• ISSNs: 2041-6520

Abstract

Abstract : A trisubstituted chiral Cp x ligand family is introduced. Abstract : A trisubstituted chiral Cp x ligand family is introduced. Based on the disubstituted atropchiral Cp x ligand scaffold, the introduction of a bulky third substituent at the central position of the Cp ring leads to substantially increased selectivities for rhodium(iii )-catalyzed kinetic resolutions and allowed for s -factors of up to 50. Their superiority is demonstrated by kinetic resolutions of phosphinic amides providing access to compounds with stereogenic phosphorus(v ) atoms. The unreacted acyclic phosphinic amide and the cyclized product are both obtained in good yields and enantioselectivities. The ligand synthesis capitalizes on a late stage modification and expands the accessible ligand Cp x ligand portfolio.