Real-time monitoring of the aggregation of Alzheimer's amyloid-β via1H magic angle spinning NMR spectroscopy. Issue 16 (7th February 2018)

• Record Type: Journal Article
• Authors: Wang, Jian; Yamamoto, Tomoya; Bai, Jia; Cox, Sarah J.; Korshavn, Kyle J.; Monette, Martine; Ramamoorthy, Ayyalusamy
• Is Part Of: Chemical communications. Volume 54:Issue 16(2018)
• Page Start: 2000
• Page End: 2003
• Publication Date: 2018-02-07
• Subjects: Chemistry -- Periodicals; 540
• DOI: 10.1039/c8cc00167g
• Languages: English
• ISSNs: 1359-7345

Abstract

Abstract : Magic-angle-spinning NMR for monitoring amyloid aggregation reveals that mechanical rotation of Aβ1–40 monomers increases the rate of aggregation. Abstract : Proton magic-angle-spinning NMR used for real-time analysis of amyloid aggregation reveals that mechanical rotation of Aβ1–40 monomers increases the rate of formation of aggregates, and that the increasing lag-time with peptide concentration suggests the formation of growth-incompetent species. EGCG's ability to shift off-pathway aggregation is also demonstrated.