Proteome-wide mapping of PQS-interacting proteins in Pseudomonas aeruginosa. Issue 8 (30th January 2018)
- Record Type:
- Journal Article
- Title:
- Proteome-wide mapping of PQS-interacting proteins in Pseudomonas aeruginosa. Issue 8 (30th January 2018)
- Main Title:
- Proteome-wide mapping of PQS-interacting proteins in Pseudomonas aeruginosa
- Authors:
- Dandela, Rambabu
Mantin, Danielle
Cravatt, Benjamin F.
Rayo, Josep
Meijler, Michael M. - Abstract:
- Abstract : Development and application of chemical probes to globally map key virulence proteins of pathogenic bacteria. Abstract : The opportunistic human pathogen Pseudomonas aeruginosa secretes 2-heptyl-3-hydroxy-4-quinolone (PQS), a quorum sensing (QS) signal that regulates the expression of numerous virulence genes. Here we report the development and application of chemical probes to globally map quinolone binding proteins. The revealed quinolone interactome contains both known as well as newly identified virulence factors and presents new targets for the treatment of bacterial infections.
- Is Part Of:
- Chemical science. Volume 9:Issue 8(2018)
- Journal:
- Chemical science
- Issue:
- Volume 9:Issue 8(2018)
- Issue Display:
- Volume 9, Issue 8 (2018)
- Year:
- 2018
- Volume:
- 9
- Issue:
- 8
- Issue Sort Value:
- 2018-0009-0008-0000
- Page Start:
- 2290
- Page End:
- 2294
- Publication Date:
- 2018-01-30
- Subjects:
- Chemistry -- Periodicals
540.5 - Journal URLs:
- http://pubs.rsc.org/en/Journals/JournalIssues/SC ↗
http://www.rsc.org/ ↗ - DOI:
- 10.1039/c7sc04287f ↗
- Languages:
- English
- ISSNs:
- 2041-6520
- Deposit Type:
- Legaldeposit
- View Content:
- Available online (eLD content is only available in our Reading Rooms) ↗
- Physical Locations:
- British Library DSC - 3151.490000
British Library DSC - BLDSS-3PM
British Library STI - ELD Digital store - Ingest File:
- 6189.xml