Characterization of the facial microbiome in twins discordant for rosacea. Issue 3 (8th March 2018)

• Record Type: Journal Article
• Authors: Zaidi, Asifa K.; Spaunhurst, Katrina; Sprockett, Daniel; Thomason, Yolandas; Mann, Margaret W.; Fu, Pingfu; Ammons, Christine; Gerstenblith, Meg; Tuttle, Marie S.; Popkin, Daniel L.
• Is Part Of: Experimental dermatology. Volume 27:Issue 3(2018)
• Page Start: 295
• Page End: 298
• Publication Date: 2018-03-08
• Subjects: 16S rRNA -- alpha and beta diversity -- microbiome -- NRS score -- relative percentage abundance; Dermatology -- Periodicals; 616.5
• DOI: 10.1111/exd.13491
• Languages: English
• ISSNs: 0906-6705

Abstract

Abstract: Previously, we determined that genetic and environmental factors contributed equally towards rosacea in twins. To assess an environmental factor, we characterized the malar cheek bacterial microbiome from twins discordant for rosacea. We found no significant difference in facial microbiome alpha and beta diversity between related twins discordant for rosacea. However, the relative percentage abundance of Gordonia and Geobacillus, low‐abundant genera, was positively and negatively associated with rosacea severity, respectively. Our data demonstrate a significant correlation between facial microbiome and severity of rosacea in genetically matched twins and importantly that overall microbiome composition is largely unchanged.