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Enatioselective Synthesis of Tetrahydrocarbazoles via Chiral Phosphoric Acid Promoted Domino Friedel–Crafts‐type Reaction of Indole‐3‐butanal with Indoles. (10th January 2018)
Record Type:
Journal Article
Title:
Enatioselective Synthesis of Tetrahydrocarbazoles via Chiral Phosphoric Acid Promoted Domino Friedel–Crafts‐type Reaction of Indole‐3‐butanal with Indoles. (10th January 2018)
Main Title:
Enatioselective Synthesis of Tetrahydrocarbazoles via Chiral Phosphoric Acid Promoted Domino Friedel–Crafts‐type Reaction of Indole‐3‐butanal with Indoles
Abstract : By employing a chiral phosphoric acid as a catalyst, enantioselective domino Friedel–Crafts‐type reaction of indole‐3‐butanal with indoles was realized. This transformation allowed for the synthesis of a wide variety of enantioenriched 1‐indolyl‐tetrahydrocarbazoles with good yields (up to 99%) in moderate enantioselectivities (up to 81% ee). Abstract :