All‐in‐one: The dream and reality of molecular cytopathology testing on routine lung cancer smears. Issue 3 (24th January 2018)

• Record Type: Journal Article
• Authors: Troncone, Giancarlo
• Is Part Of: Cancer cytopathology. Volume 126:Issue 3(2018)
• Page Start: 155
• Page End: 157
• Publication Date: 2018-01-24
• Subjects: Cancer -- Cytopathology -- Periodicals; Pathology, Cellular -- Periodicals; Cytology -- Technique -- Periodicals; 611.01815
• DOI: 10.1002/cncy.21962
• Languages: English
• ISSNs: 1934-662X

Abstract

Abstract : If cytopathologists are used to dedicating 1 or more fine‐needle aspiration passes to prepare a tumor‐representative cell block, the testing laboratory may strongly rely on anaplastic lymphoma kinase (ALK), ROS proto‐oncogene 1, receptor tyrosine kinase (ROS1), and programmed death‐ligand 1 (PD‐L1) immunocytochemistry assays. Conversely, when sample procurement and diagnostic interpretation are based primarily on smeared material, cytopathologists should promote, in conjunction with the molecular team, ALK and ROS1 RNA‐based testing approaches on smears, saving the cell block only for PD‐L1 staining. See also pages 158‐69.