Adipose‐derived stem cells decrease cardiomyocyte damage induced by porphyromonas gingivalis endotoxin through suppressing hypertrophy, apoptosis, fibrosis, and MAPK markers. Issue 4 (31st January 2018)

• Record Type: Journal Article
• Authors: Chen, Tung‐Sheng; Kuo, Chia‐Hua; Battsengel, Sarnai; Pan, Lung‐Fa; Day, Cecilia Hsuan; Shen, Chia‐Yao; Chung, Li‐Chin; Padma, V. Vijaya; Yao, Chen‐Kai; Lin, Yueh‐Min; Huang, Chih‐Yang
• Is Part Of: Environmental toxicology. Volume 33:Issue 4(2018)
• Page Start: 508
• Page End: 513
• Publication Date: 2018-01-31
• Subjects: cardiomyopathy -- endotoxin -- IGF1 -- periodontal disease -- stem cell; Water quality bioassay -- Periodicals; Water -- Pollution -- Toxicology -- Periodicals; Microbiological assay -- Periodicals; Toxicity testing -- Periodicals; Environmental toxicology -- Periodicals; Environmental Pollution -- Periodicals; Environmental Pollutants -- Periodicals; Environmental Monitoring -- Periodicals; Écotoxicologie -- Périodiques; Pollution -- Périodiques; 615.902
• DOI: 10.1002/tox.22536
• Languages: English
• ISSNs: 1520-4081

Abstract

Abstract: Heart failure is one of the complications related to periodontal disease. In addition to drugs or herbal medicines, stem cell therapy shows potential in the treatment of cardiomyopathy. This study investigates if stem cells exhibit beneficial effects on cardiomyocyte damage induced by porphyromonas gingivalis endotoxin (Pg‐LPS). From the experimental results we find that Pg‐LPS reduce cardiomyocyte viability via the activation of apoptosis, hypertrophy, fibrosis and MAPK signaling. Pg‐LPS damaged cardiomyocytes co‐cultured with adipose‐derived stem cells (ADSC) increases cardiomyocyte viability through suppressing the pathological markers described above. Further evidence implies that survival marker, IGF1, secreted from ADSC, may play an important role in the Pg‐LPS induced protective effect on cardiomyocyte damage.