Thyroid carcinoma producing β‐human chorionic gonadotropin shows different clinical behavior. Issue 4 (15th February 2018)

• Record Type: Journal Article
• Authors: Gu, Haiyan; Sui, Shaofeng; Cui, Xiujie; Han, Bo; Zhang, Chunyan; Qi, Mei; Li, Congcong; Liu, Zhiyan
• Is Part Of: Pathology international. Volume 68:Issue 4(2018)
• Page Start: 207
• Page End: 213
• Publication Date: 2018-02-15
• Subjects: clinicopathological feature -- columnar cell variant -- papillary thyroid carcinoma -- paraneoplastic hyperthyroidism -- β‐hCG; Pathology -- Periodicals; 616.07
• DOI: 10.1111/pin.12639
• Languages: English
• ISSNs: 1320-5463

Abstract

Abstract : Columnar cell variant of papillary thyroid carcinoma (CCV‐PTC) is an unusual neoplasm, the clinical behavior of which mainly depends on the encapsulation or infiltration. Patients with extensive extrathyroidal extension usually have an aggressive biological behavior. This study confirmed that beta‐human chorionic gonadotropin (β‐hCG) secreting invasive CCV‐PTC has good prognosis comparing with a cohort of follicular cell differentiated thyroid carcinoma. On the contrary, positive immunoreaction with β‐hCG was proved in three anaplastic thyroid carcinoma patients showing aggressive clinical courses. The clinicopathologic characteristics of CCV‐PTC and the paraneoplastic syndromes in follicular cell differentiated thyroid carcinoma were further summarized using literature review.