Serum levels and ApaI polymorphism of insulin-like growth factor 2 on intrauterine growth restriction infants. (3rd June 2018)

• Record Type: Journal Article
• Authors: Hăşmăşanu, Monica G.; Baizat, Melinda; Procopciuc, Lucia Maria; Blaga, Ligia; Văleanu, Mădălina A.; Drugan, Tudor C.; Zaharie, Gabriela C.; Bolboacă, Sorana D.
• Is Part Of: Journal of maternal-fetal & neonatal medicine. Volume 31:Number 11(2018)
• Page Start: 1470
• Page End: 1476
• Publication Date: 2018-06-03
• Subjects: Intrauterine growth restriction (IUGR) -- insulin-like growth factor 2 (IGF2) -- insulin-like growth factor 2 receptor (IGF2R) -- single nucleotide polymorphisms (SNPs); Obstetrics -- Periodicals; Perinatology -- Periodicals; Infants (Newborn) -- Diseases -- Periodicals; Neonatology -- Periodicals; 618.2
• DOI: 10.1080/14767058.2017.1319921
• Languages: English
• ISSNs: 1476-7058

Abstract

Abstract: Purpose: The aim of our study was to evaluate the IGF2 and IGF2R plasmatic level and IGF2- Apa I polymorphism on infants with intrauterine growth restriction (IUGR). Materials and methods: A transversal study was conducted at the Neonatology Ward of the Gynecology Clinic I, Emergency Hospital Cluj-Napoca on neonates with IUGR who were discharged during June 2014 and June 2015. The serum levels of IGF2 and IGF2R were obtained by using ELISA method and IGF2- Apa I polymorphism by taking PCR-RFLP analysis. Results: Forty infants with IUGR and 21 infants of appropriate gestational age (AGA) were evaluated. The serum levels of IGF2 proved higher on the A/G genotype when the IUGR group was compared with AGA ( p value = .048). The G allele proved significantly more frequent in both the IUGR and the AGA group compared with the A allele ( p < .002). Neither any allele nor any genotype proved a risk factor for IUGR ( p value > .3). The A/G genotype proved significantly more frequent on term infants compared with preterm infants ( p value = .039). Conclusions: The infant with IUGR has a higher serum level of IGF2 if has A/G IGF2- Apa I genotype and higher values of IGF2R if it has the A/A genotype.