Value of clinical features to differentiate refractory epilepsy from mimics: a prospective longitudinal cohort study. (1st March 2018)

• Record Type: Journal Article
• Authors: Labate, A.; Mumoli, L.; Curcio, A.; Tripepi, G.; D'Arrigo, G.; Ferlazzo, E.; Aguglia, U.; Indolfi, C.; Quattrone, A.; Gambardella, A.
• Is Part Of: European journal of neurology. Volume 25:Number 5(2018)
• Page Start: n/a
• Page End: n/a
• Publication Date: 2018-03-01
• Subjects: AEDs -- psychogenic non‐epileptic seizure -- refractory epilepsy -- syncope; Neurology -- Periodicals; Nervous system -- Diseases -- Periodicals; 616.8
• DOI: 10.1111/ene.13579
• Languages: English
• ISSNs: 1351-5101

Abstract

Abstract : Background and purpose: Misdiagnosis of refractory epilepsy (rE) is common and such patients experience a long diagnostic delay. Our aim was to identify key clinical/laboratory factors in order to obtain an alternative diagnosis in patients referred for rE. Methods: Between January 2010 and December 2015, 125 consecutive patients with a diagnosis of rE were prospectively enrolled. All patients underwent a comprehensive neurological, neuropsychiatric and cardiological evaluation, and had an observation time of at least 1 year after the study entry. Results: Diagnosis of rE was confirmed in 104/125 (83.2%) patients (55 women, mean age 38.8 ± 14.3 years). Thirteen/125 patients (10.4%, seven women, mean age 50.8 ± 20.9) were diagnosed with syncope, which was cardiac/cardio inhibitory in 9/13 (69%). The remaining 8/125 patients (6.4%, six women, mean age 41.2 ± 14.6 years) were diagnosed with psychogenic non‐epileptic seizures. Age at onset had a high accuracy in differentiating patients with syncope from others, with the best cut‐off age at 35 years and above. Abnormal brain magnetic resonance imaging (MRI) had a significant yield of about 70% in rE. A diagnostic model including age at onset and brain MRI was highly accurate in differentiating patients with syncope from others. In patients with cardiac/cardio inhibitory syncope, the point score of historical features was ≥1 and falsely favoured the diagnosis of epileptic seizures. Conclusions: This prospective cohort study identifies rE mimics who are at high risk of morbidity and mortality. rE starting in adulthood should raise a high suspicion of cardiac syncope. Brain MRI is accurate in differentiating rE from other conditions.