Diagnostic accuracy of fecal immunochemical test in average- and familial-risk colorectal cancer screening. Issue 6 (December 2014)

• Record Type: Journal Article
• Authors: Cubiella, Joaquín; Castro, Inés; Hernandez, Vicent; González-Mao, Carmen; Rivera, Concepción; Iglesias, Felipe; Alves, María Teresa; Cid, Lucía; Soto, Santiago; De-Castro, Luisa; Vega, Pablo; Hermo, Jose Antonio; Macenlle, Ramiro; Martínez, Alfonso; Estevez, Pamela; Cid, Estela; Herreros-Villanueva, Marta; Portillo, Isabel; Bujanda, Luis; Fernández-Seara, Javier
• Is Part Of: United European Gastroenterology journal. Volume 2:Issue 6(2014:Dec.)
• Page Start: 522
• Page End: 529
• Publication Date: 2014-12
• Subjects: Colorectal cancer -- colorectal adenoma -- fecal immunochemical test -- colonoscopy -- familial colorectal cancer -- colorectal cancer screening -- sensitivity and specificity; Gastroenterology -- Periodicals; Periodicals; 616.33005
• DOI: 10.1177/2050640614553285
• Languages: English
• ISSNs: 2050-6406

Abstract

Background: There is little information about the fecal immunochemical test (FIT) in familial-risk colorectal cancer (CRC) screening. Objectives: The objective of this article is to investigate whether FIT diagnostic accuracy for advanced neoplasia (AN) differs between average and familial-risk (first-degree relative) patients. Methods: A total of 1317 consecutive participants (595 familial) who collected one stool sample before performing a colonoscopy as a CRC screening test were included. FIT diagnostic accuracy for AN was evaluated with Chi-square test at a 20 µg hemoglobin/g of feces cut-off value. Finally, we determined which variables were independently related to AN. Results: An AN was found in 151 (11.5%) patients. The overall accuracy was not statistically different between both cohorts for AN (88.4%, 91.7%; p = 0.051). At the cut-off stablished, differences in FIT sensitivity (31.1%, 40.6%; p = 0.2) or specificity (96.5%, 97.3%; p = 0.1) were not statistically significant. Finally, independent variables such as sex (male) (odds ratio (OR) 2.1, 95% confidence interval (CI) 1.4–3.1), age (50–65, >65 years) (OR 2.1, 95% CI 1.1–4.3; OR 2.7, 95% CI 1.2–6.1), previous colonoscopy (OR 0.4, 95% CI 0.2–0.9) and FIT ≥20 µg/g feces (OR 17.7, 95% CI 10.8–29.1) were associated with AN diagnosis. Conclusions: FIT accuracy for AN detection is equivalent in average and familial-risk CRC screening cohorts.