Syntheses and evaluation of new acridone derivatives for selective binding of oncogene c-myc promoter i-motifs in gene transcriptional regulation. Issue 16 (7th February 2018)

• Record Type: Journal Article
• Authors: Shu, Bing; Cao, Jiaojiao; Kuang, Guotao; Qiu, Jun; Zhang, Meiling; Zhang, Yan; Wang, Mingxue; Li, Xiaoya; Kang, Shuangshuang; Ou, Tian-Miao; Tan, Jia-Heng; Huang, Zhi-Shu; Li, Ding
• Is Part Of: Chemical communications. Volume 54:Issue 16(2018)
• Page Start: 2036
• Page End: 2039
• Publication Date: 2018-02-07
• Subjects: Chemistry -- Periodicals; 540
• DOI: 10.1039/c8cc00328a
• Languages: English
• ISSNs: 1359-7345

Abstract

Abstract : We synthesized a series of acridone derivatives for specific binding ligands of i-motifs. Abstract : We synthesized a series of acridone derivatives for specific binding ligands of i-motifs. Subsequent evaluations showed thatB19 could selectively bind to and stabilize the c- myc promoter i-motif without significant binding to the G-quadruplex and duplex DNA. This caused down-regulation of c- myc transcription and expression, resulting in tumor cell apoptosis.