Adventures in radiosynthesis of clinical grade [68Ga]Ga-DOTA-Siglec-9. Issue 15 (20th February 2018)

• Record Type: Journal Article
• Authors: Käkelä, Meeri; Luoto, Pauliina; Viljanen, Tapio; Virtanen, Helena; Liljenbäck, Heidi; Jalkanen, Sirpa; Knuuti, Juhani; Roivainen, Anne; Li, Xiang-Guo
• Is Part Of: RSC advances. Volume 8:Issue 15(2018)
• Page Start: 8051
• Page End: 8056
• Publication Date: 2018-02-20
• Subjects: Chemistry -- Periodicals; 540.5
• DOI: 10.1039/c7ra12423f
• Languages: English
• ISSNs: 2046-2069

Abstract

Abstract : [ 68 Ga]Ga-DOTA-Siglec-9 is the first vascular adhesion protein-1 targeting radiopharmaceutical for positron emission tomography imaging of inflammation, and here we present its long-awaited clinical grade radiosynthesis. Abstract : We finally managed to establish a protocol for generating Good Manufacturing Practice (GMP)-grade gallium-68-labelled 1, 4, 7, 0-tetraazacyclododecane-1, 4, 7, 10-tetraacetic acid conjugated sialic acid-binding immunoglobulin-like lectin 9 motif containing peptide ([ 68 Ga]Ga-DOTA-Siglec-9), the first radiopharmaceutical for positron emission tomography imaging of vascular adhesion protein 1.