An uncommon multicomponent reaction involving nucleophilic heterocyclic carbenes: facile synthesis of fully substituted cyclopentanones. Issue 7 (7th February 2018)

• Record Type: Journal Article
• Authors: Krishnan, Jagadeesh; Jose, Anu; Sasidhar, B. S.; Suresh, E.; Menon, Rajeev S.; Nair, Vijay
• Is Part Of: Organic chemistry frontiers. Volume 5:Issue 7(2018)
• Page Start: 1202
• Page End: 1208
• Publication Date: 2018-02-07
• Subjects: Chemistry, Organic -- Periodicals; 547.005
• DOI: 10.1039/c7qo01051f
• Languages: English
• ISSNs: 2052-4110

Abstract

Abstract : An unprecedented three component reaction involving arylidene oxazolone, enal and NHC, leading to the synthesis of fully substituted cyclopentanone derivatives with three contiguous stereocenters, is reported. Abstract : An unprecedented three component reaction involving arylidene oxazolone, enal and NHC, leading to the synthesis of fully substituted cyclopentanone derivatives with three contiguous stereocenters, is reported. This reaction illustrates the rare example of a multicomponent process involving NHCs, where the NHC-bound enolate is isolated by the interception of the NHC-homoenolate with arylidene oxazolone.