Phosphorus‐nitrogen compounds. Part 39. Syntheses and Langmuir‐Blodgett thin films and antimicrobial activities of N/N and N/O spirocyclotriphosphazenes with monoferrocenyl pendant arm. (17th January 2018)

• Record Type: Journal Article
• Authors: Asmafiliz, Nuran; Civan, Mehmet; Özben, Arda; Kılıç, Zeynel; Ramazanoğlu, Nagehan; Açık, Leyla; Hökelek, Tuncer
• Is Part Of: Applied organometallic chemistry. Volume 32:Number 4(2018)
• Page Start: n/a
• Page End: n/a
• Publication Date: 2018-01-17
• Subjects: antimicrobial activity -- crystal structure -- Langmuir‐Blodgett thin films spiroferrocenylphosphazenes -- spectroscopy; Organometallic chemistry -- Periodicals; Organometallic compounds -- Periodicals; 547.05
• DOI: 10.1002/aoc.4223
• Languages: English
• ISSNs: 0268-2605

Abstract

Abstract : The Cl substitution reactions of the N/N (1 ‐3 ) and N/O (4 and5 ) spirocyclic monoferrocenylphosphazenes with 1, 4‐dioxa‐8‐azaspiro[4, 5]decane (DASD) produce the mono‐ (1a ‐5a ), geminal‐ (1b ‐5b ) and tetrakis‐DASD‐substituted ferrocenylspirocyclotriphosphazenes (1c ‐5c ). The mono‐ and geminal‐DASD‐substituted phosphazenes have two and one stereogenic P‐centers, respectively. The structures of the compounds were established by spectroscopic techniques. The molecular structures of3a and2b were evaluated using X‐ray crystallography. Additionally, the ultrathin and highly ordered Langmuir‐Blodgett (LB) films of3a and2b were also prepared. The characterizations of the LB films were done using p‐polarized grazing angle (GAIR) and horizontal attenuated total reflectance (HATR) techniques. On the other hand, the antimicrobial activities of the eight phosphazene derivatives against G(+) and G(‐) bacteria and fungi were investigated. Furthermore, the interactions between the compounds and plasmid DNA were studied by agarose gel electrophoresis. Abstract : The new partly and fully‐DASD‐substituted spirocyclotriphosphazenes were prepared. The structures of these compounds were determined. The ultrathin and highly ordered LB films of the two compounds were fabricated. The new phosphazenes were screened for antimicrobial activity. The interactions between the compounds and pBR322 plasmid DNA were investigated.