Preclinical Studies of Stem Cell Therapy for Heart Disease. Issue 7 (30th March 2018)

• Record Type: Journal Article
• Authors: Tompkins, Bryon A.; Balkan, Wayne; Winkler, Johannes; Gyöngyösi, Mariann; Goliasch, Georg; Fernández-Avilés, Francisco; Hare, Joshua M.
• Is Part Of: Circulation research. Volume 122:Issue 7(2018)
• Publication Date: 2018-03-30
• Subjects: heart failure -- infarction -- regenerative medicine -- stem cells; Cardiovascular system -- Periodicals; Blood -- Circulation -- Periodicals; Blood Circulation; Cardiovascular System; Vascular Diseases; Sang -- Circulation -- Périodiques; Appareil cardiovasculaire -- Périodiques; 612.1
• DOI: 10.1161/CIRCRESAHA.117.312486
• Languages: English
• ISSNs: 0009-7330

Abstract

Abstract : As part of the TACTICS (Transnational Alliance for Regenerative Therapies in Cardiovascular Syndromes) series to enhance regenerative medicine, here, we discuss the role of preclinical studies designed to advance stem cell therapies for cardiovascular disease. The quality of this research has improved over the past 10 to 15 years and overall indicates that cell therapy promotes cardiac repair. However, many issues remain, including inability to provide complete cardiac recovery. Recent studies question the need for intact cells suggesting that harnessing what the cells release is the solution. Our contribution describes important breakthroughs and current directions in a cell-based approach to alleviating cardiovascular disease.