Asymmetric Synthesis of Spiro β‐Lactams via a Squaramide‐ Catalyzed Sulfa‐Michael Addition/Desymmetrization Protocol. Issue 20 (31st August 2016) - Chauhan, Pankaj
Abstract: An efficient asymmetric synthesis of spirocyclohexenone β‐lactams bearing three contiguous stereocenters has been achieved in moderate to good yields and high stereoselectivities. The protocol involves the combination of a squaramide‐catalyzed sulfa‐Michael addition under desymmetrization via a dynamic kinetic resolution of racemic 2, 5‐cyclohexadienones. Abstract :