MPS 14-01 EFFECT OF ALLOPURINOL IN REDUCING BLOOD PRESSURE IN HYPERTENSION WITH HYPERURICEMIA PATIENTS IN DR. MOHAMMAD HOESIN HOSPITAL PALEMBANG. (September 2016)

• Record Type: Journal Article
• Authors: Ali, Zulkhair; Mulia, Deddy Primadona; Effendi, Ian; Suhaimi, Novadian; Suprapti, Suprapti; Taruna, Ahmad; Rahmayani, Febry
• Is Part Of: Journal of hypertension. Volume 34:(2016) Supplement 1
• Publication Date: 2016-09
• Subjects: Hypertension -- Periodicals; Hypertension -- Periodicals; 616.132005
• DOI: 10.1097/01.hjh.0000501056.74804.dc
• Languages: English
• ISSNs: 1473-5598

Abstract

Abstract : Objective: Hyperuricemia will activate Rennin Angiotensin Aldosteron System (RAAS) through activation of Angiotensin I to Angiotensin II, increase intraglomerulus pressure, macrophage activator and cytokines production, vascular vasoconstriction. This process caused glomerulus fibrosis, natrium retention, increasing of blood volume and hypertension. Otherwise, overreaction of xanthine oxide in hyperuricemia will produce uncoupling mechanoenergetic and myocardial apoptosis. These conditions activate remodelling vascular and tissue injury, endothelial dysfunction and ended to atherosclerosis, hypertension and heart failure. Lately, Toma et all reported that uric acid stimulates the release of rennin by the macula densa dependent mechanism using micro vitro perfusion afferent arteriols in glomerular. Feig demonstrate that allopurinol treatment can lower systolic and diastolic blood pressure compared to placebo. The mechanism of allopurinol lower blood pressure is lowering systemic vascular resistance and plasma rennin activity. Design and Method: Study was a double blind randomized clinical trial in the outpatient clinic and the inpatient ward of internal medicine since February to September 2015. Results: Allopurinol Effect on blood pressure was measuring the systolic blood pressure and diastolic blood pressure before and after 8 weeks of drug administration. The mean systolic blood pressure before and after drug administration allopurinol group were 148, 33 ± 13, 394 mmHg and 135, 00 ± 9, 85 mmHg, respectively, while in placebo group was 151, 67 ± 13, 394 mmHg and 146, 11 ± 6, 78 mmHg, respectively. The diastolic blood pressure before allopurinol administration was 88, 67 ± 3, 45 mmHg, and 79, 00 ± 4, 02 mmHg after therapy. In placebo group, diastolic before and after placebo administration were 92, 22 ± 7, 321 and 91, 94 ± 5, 185, consecutively. Statistic test showed that there was a significant difference of systolic blood pressure before and after allopurinol administration compare to placebo (p = 0, 001), and diastolic blood pressure before and after giving allopurinol compare to placebo p = 0, 000. Conclusions: Allopurinol had significant effect on lowering systolic and diastolic blood pressure. Figure. No caption available.