LBPS 01–01 NEW EFFECTS OF EXERCISE TRAINING ON HYPERTENSIVE HEARTS. (September 2016)

• Record Type: Journal Article
• Authors: Lee, Shin-Da
• Is Part Of: Journal of hypertension. Volume 34:(2016) Supplement 1
• Publication Date: 2016-09
• Subjects: Hypertension -- Periodicals; Hypertension -- Periodicals; 616.132005
• DOI: 10.1097/01.hjh.0000500371.71901.51
• Languages: English
• ISSNs: 1473-5598

Abstract

Abstract : Objective: The purpose was to evaluate the anti-inflammatory, anti-apoptotic, pro-survival, anti-fibrotic effects of exercise training on hypertensive diabetic hearts. Design and method: SHR hypertension rats were divided into sedentary group (SHR) and underwent running exercise on treadmill 1 hour daily, 5 sections per week, for 12 weeks (SHR-EX). Age-matched WKY rats served as a sedentary normal group (WKY). After exercise training or sedentary status, the excised hearts were measured by H&E staining, TUNEL assay and Western Blotting. Results: TUNEL-positive apoptotic cells became less in SHR-EX groups than those in SHR. Serum and Cardiac TNF-alpha were decreased in SHR-EX relative to SHR. Protein levels of Fas ligand, Fas death receptor, TNF-α, TNF receptor 1, Fas-associated death domain (FADD), activated caspase-8, and activated caspase-3 (Fas-dependent apoptotic pathways), as well as t-Bid, Bad, Bak, cytochrome c, activated caspase 9 and activated caspase-3 (mitochondria-dependent apoptotic pathways) were decreased in SHR-EX group compared with SHR group. Cardiac TGF-beta and CTGF were decreased in SHR-EX group compared with SHR group. Conclusions: Conclusions. Exercise training prevented hypertension-enhanced cardiac Fas-dependent and mitochondria-dependent apoptotic pathways and enhanced cardiac pro-survival pathway in rat models. Exercise training prevented hypertension-enhanced cardiac fibrotic pathways.Our findings demonstrate new therapeutic effects of exercise training on hypertensive hearts for preventing apoptosis. Research was supported by The Program for Professor of Special Appointment (Eastern Scholar, Honorary Chair Professor) at Shanghai Institute of Higher Education (No 2012-47).