Flare on Serial Prostate-Specific Membrane Antigen–Targeted 18F-DCFPyL PET/CT Examinations in Castration-Resistant Prostate Cancer: First Observations. (March 2018)

• Record Type: Journal Article
• Authors: Zukotynski, Katherine A.; Valliant, John; Bénard, François; Rowe, Steven P.; Kim, Chun K.; Pomper, Martin G.; Cho, Steve Y.
• Is Part Of: Clinical nuclear medicine. Volume 43:Number 3(2018)
• Publication Date: 2018-03
• Subjects: PET/CT -- prostate cancer -- PSMA -- 18F-DCFPyL; Nuclear medicine -- Periodicals; Radioisotope scanning -- Periodicals; Nuclear Medicine -- Periodicals; 616.07575
• DOI: 10.1097/RLU.0000000000001966
• Languages: English
• ISSNs: 0363-9762

Abstract

Abstract : Abstract: A 71-year-old man with castration-resistant prostate cancer demonstrated a flare phenomenon on 99m Tc-MDP and CT after 10 weeks of enzalutamide. Prostate-specific membrane antigen–targeted 18 F-DCFPyL PET/CT demonstrated minimal uptake at sites of baseline bone and lymph node disease with increasing uptake at sites of osseous disease following therapy. Although this is likely related in part to decreased androgen receptor activity and a consequent increase in prostate-specific membrane antigen expression, other mechanisms (neovascularization, cell infiltration from the bone repair process, osteoblastic turnover, or minimal radiotracer impurity) may also be involved in causing the increased 18 F-DCFPyL uptake at sites of osseous flare.