Ultraviolet light and melanoma. Issue 5 (5th March 2018)

• Record Type: Journal Article
• Authors: Craig, Sarah; Earnshaw, Charles H; Virós, Amaya
• Editors: Huntsman, David G; Ladanyi, Marc
• Is Part Of: Journal of pathology. Volume 244:Issue 5(2018)
• Page Start: 578
• Page End: 585
• Publication Date: 2018-03-05
• Subjects: skin -- epidermis -- acute inflammation; Pathology -- Periodicals; 616.07
• DOI: 10.1002/path.5039
• Languages: English
• ISSNs: 0022-3417

Abstract

Abstract: Melanoma is a clinically heterogeneous disease, and current strategies for treatment of the primary tumour are based on pathological criteria alone. In the recent past, several DNA‐sequencing and RNA‐sequencing studies of primary and advanced melanoma samples have identified unique relationships between somatic mutations, genomic aberrations, and the genetic fingerprint of ultraviolet radiation (UVR). The recurrent patterns of genomic alterations reveal different disease pathways, drug targets and mechanisms limiting drug response. Here, we examine the known associations between the molecular categories of melanoma and the multidimensional UVR damage. Copyright © 2018 Pathological Society of Great Britain and Ireland. Published by John Wiley & Sons, Ltd.