The microbiome and cancer. Issue 5 (12th March 2018)

• Record Type: Journal Article
• Authors: Goodman, Brian; Gardner, Humphrey
• Editors: Huntsman, David G; Ladanyi, Marc
• Is Part Of: Journal of pathology. Volume 244:Issue 5(2018)
• Page Start: 667
• Page End: 676
• Publication Date: 2018-03-12
• Subjects: microbiome -- next‐generation sequencing -- evolution of cancer -- metabolomics of cancer; Pathology -- Periodicals; 616.07
• DOI: 10.1002/path.5047
• Languages: English
• ISSNs: 0022-3417

Abstract

Abstract: Humans coexist with a vast bacterial, fungal and viral microbiome with which we have coevolved for millions of years. Several long recognized epidemiological associations between particular bacteria and cancer are now understood at the molecular level. At the same time, the arrival of next‐generation sequencing technology has permitted a thorough exploration of microbiomes such as that of the human gut, enabling observation of taxonomic and metabolomic relationships between the microbiome and cancer. These studies have revealed causal mechanisms for both microbes within tumours and microbes in other host niches separated from tumours, mediated through direct and immunological mechanisms. Copyright © 2018 Pathological Society of Great Britain and Ireland. Published by John Wiley & Sons, Ltd.