Effects of a new combination of  plant extracts plus d-mannose for the management of uncomplicated recurrent urinary tract infections. (17th February 2018)

• Record Type: Journal Article
• Authors: Genovese, Carlo; Davinelli, Sergio; Mangano, Katia; Tempera, Gianna; Nicolosi, Daria; Corsello, Salvatore; Vergalito, Franca; Tartaglia, Edoardo; Scapagnini, Giovanni; Di Marco, Roberto
• Is Part Of: Journal of chemotherapy. Volume 30:Number 2(2018)
• Page Start: 107
• Page End: 114
• Publication Date: 2018-02-17
• Subjects: Plant extracts -- Recurrent urinary tract infections -- Cystitis -- Prevention -- d-mannose; UTIs, urinary tract infections -- cAMP, cyclic adenosine monophosphate -- UPEC, uropathogenic Escherichia coli -- GFR, glomerular filtration rate -- CFU, colony-forming units -- CLSI, Clinical and Laboratory Standards Institute -- LBG, lactobacillus grade; Chemotherapy -- Periodicals; Drug Therapy -- Periodicals; 615.58
• DOI: 10.1080/1120009X.2017.1393587
• Languages: English
• ISSNs: 1120-009X

Abstract

Abstract : Urinary tract infections (UTIs) are an economic burden for public health. The increasing prevalence of resistant bacteria which cause UTIs may be related to the inappropriate prescription of antibiotics. The aim of this preliminary study was to evaluate whether three different combinations of plant extracts plusd -mannose are effective in preventing the recurrence of UTIs. Three groups of patients received three combinations of plant extracts in conjunction withd -mannose. These were: berberine, arbutin and birch (group A); berberine, arbutin, birch and forskolin (group B); and proanthocyanidins (group C). The clinical recurrence of cystitis at the end of treatment and during follow-up was determined by comparison with baseline measurements using the microbiological assessment of urine samples, vaginal swabs and vaginal smear slides. Patients in groups A and B had a lower incidence of episodes of recurrent cystitis during treatment and follow-up, samples with a significantly lower median bacterial load and a reduction of the grade of lactobacillary flora compared to patients in group C.