C21 steroidal glycosides from Cynanchum taihangense. Issue 3 (4th March 2018)

• Record Type: Journal Article
• Authors: Wang, Yu-Bo; Su, Shan-Shan; Chen, Shao-Fei; Tang, Ming-Xu; Chen, Gang; Zhao, Dan; Sang, Xia-Nan; Si, Ying-Ying; Wang, Hai-Feng; Pei, Yue-Hu
• Is Part Of: Journal of Asian natural products research. Volume 20:Issue 3(2018)
• Page Start: 263
• Page End: 269
• Publication Date: 2018-03-04
• Subjects: Asclepiadaceae -- Cynanchum taihangense -- steroidal glycosides -- deoxypyranoses -- cytotoxicity -- NMR data; Materia medica -- Asia -- Periodicals; Pharmacognosy -- Asia -- Periodicals; Medicinal plants -- Asia -- Periodicals; Medicine, Oriental -- Asia -- Periodicals; 615.321095
• DOI: 10.1080/10286020.2017.1329302
• Languages: English
• ISSNs: 1028-6020

Abstract

Abstract: Two new C21 steroidal glycosides, cynataihosides E (1 ) and F (2 ), together with a known one, sublanceoside H2 (3 ), were isolated from Cynanchum taihangense . The aglycone of cynataihoside F (2 ) was also a new compound. Their structures were elucidated on the basis of NMR spectroscopic data, HR-ESI-MS analysis, and chemical evidence. Their cytotoxic activities against three human tumor cell lines (HL-60, THP1, and Caco2) were reported. Graphical Abstract: