Cognitive Impairment Among Elderly Individuals in Shanghai Suburb, China: Association of C-Reactive Protein and its Interactions With Other Relevant Factors. (December 2014)

• Record Type: Journal Article
• Authors: Chen, Jin-Mei; Cui, Guo-Hong; Jiang, Guo-Xin; Xu, Rui-Fang; Tang, Hui-Dong; Wang, Gang; Chen, Sheng-Di; Cheng, Qi
• Is Part Of: American journal of Alzheimer's disease & other dementias. Volume 29:Number 8(2014)
• Page Start: 712
• Page End: 717
• Publication Date: 2014-12
• Subjects: cognitive impairment -- C-reactive protein -- interaction -- risk factor; Alzheimer's disease -- Periodicals; Dementia -- Periodicals; Alzheimer's disease -- Patients -- Care -- United States -- Periodicals; 616.83
• DOI: 10.1177/1533317514534758
• Languages: English
• ISSNs: 1533-3175

Abstract

Objectives: To investigate the association between serum C-reactive protein (CRP) concentration and cognitive impairment as well as interactions between CRP and other relevant factors. Methods: Patients with cognitive impairment and 1 to 2 age- and sex-matched controls nested from a population-based study among residents aged 60 years and older in Shanghai suburb. The associations of serum CRP concentration and other relevant factors were examined with logistic regression analysis. Results: The mean CRP in patients with cognitive impairment was higher than that in controls ( P < .001). The highest quartile of CRP (>4.77 mg/L), abdomen obesity, hypertriglyceridemia, and hyperglycemia was associated with cognitive impairment. Significant interactions were found between increased CRP and hypertriglyceridemia as well as between increased CRP and hyperglycemia on cognitive impairment; and the attributable proportion due to interaction was 82% ( P < .0001) and 37% ( P = .007), respectively. Conclusions: Increased CRP was associated with cognitive impairment, and additive effects of increased CRP with hypertriglyceridemia and hyperglycemia on cognitive impairment were observed among elderly individuals.