Evaluation of biofilm formation on novel copper-catalyzed azide-alkyne cycloaddition (CuAAC)-based resins for dental restoratives. Issue 4 (April 2018)

• Record Type: Journal Article
• Authors: Zajdowicz, Sheryl; Song, Han Byul; Baranek, Austin; Bowman, Christopher N.
• Is Part Of: Dental materials. Volume 34:Issue 4(2018)
• Page Start: 657
• Page End: 666
• Publication Date: 2018-04
• Subjects: Dental materials -- Biofilm -- Streptococcus mutans -- Dental resin composites -- Copper-catalyzed azide-alkyne polymerization; Dentistry -- Periodicals; Dental materials -- Periodicals; 617.695
• DOI: 10.1016/j.dental.2018.01.011
• Languages: English
• ISSNs: 0109-5641

Abstract

Highlights: Biofilm formation on the surface of CuAAC-based resins and composites was assessed. A significant reduction in biofilm bioburden was observed on CuAAC-based materials. Longevity of dental restorations that contain CuAAC-based materials may be enhanced. Abstract: Objective: For the past several decades, the resins used in dental restorations have been plagued with numerous problems, including their implication in biofilm formation and secondary caries. The need for alternative resins is critical, and evaluation of biofilm formation on these resins is essential. The aim of this study was to evaluate in vitro biofilm formation on the surface of novel copper(I)-catalyzed azide-alkyne cycloaddition (CuAAC)-based resins and composites. Methods: CuAAC-based resins/composites made from varying azide monomers and different copper concentrations were compared with BisGMA-TEGDMA resins/composites that served as the control. Biofilms were formed using a mono-species model containing a luciferase-expressing strain of Streptococcus mutans . Luciferase activity was measured and the number of viable bacteria was enumerated on biofilms associated with each resin and composite. Results: A significant reduction (p < 0.05) in luciferase activity, and the number of viable bacteria recovered from biofilms on CuAAC-based resins and composites was observed in comparison to biofilms associated with the BisGMA-TEGDMA controls. Significance: CuAAC-based resins do still allow for the formation of biofilms; however, the statistically significant reduction of growth that was associated with the CuAAC resin may enhance the longevity of restorations that incorporate CuAAC-based materials.