Approach to pactamycin analogues using rhodium(ii)-catalyzed alkene aziridination and C(sp3)–H amination reactions. Issue 6 (21st December 2017)

• Record Type: Journal Article
• Authors: Rodrigues, Romain; Lazib, Yanis; Maury, Julien; Neuville, Luc; Leboeuf, David; Dauban, Philippe; Darses, Benjamin
• Is Part Of: Organic chemistry frontiers. Volume 5:Issue 6(2018)
• Page Start: 948
• Page End: 953
• Publication Date: 2017-12-21
• Subjects: Chemistry, Organic -- Periodicals; 547.005
• DOI: 10.1039/c7qo00878c
• Languages: English
• ISSNs: 2052-4110

Abstract

Abstract : Application of dirhodium(ii )-catalyzed nitrene transfers allows for the preparation of a platform bearing the triamino moiety present in pactamycin. Abstract : Dirhodium(ii )-catalyzed nitrene transfers have been used to prepare a novel synthetic platform bearing the triamino moiety present in pactamycin, jogyamycin and cranomycin. Catalytic intramolecular C(sp 3 )–H amination and alkene aziridination reactions, the latter followed by a nucleophilic aziridine ring opening, are the key steps of this strategy.