A patient with central nervous system tuberculomas and a history of disseminated multi-drug-resistant tuberculosis. (January 2018)

• Record Type: Journal Article
• Authors: Kaplan, Samantha R.; Topal, Jeffrey; Sosa, Lynn; Malinis, Maricar; Huttner, Anita; Malhotra, Ajay; Friedland, Gerald
• Is Part Of: Journal of clinical tuberculosis and other mycobacterial diseases. Volume 10(2018)
• Page Start: 9
• Page End: 16
• Publication Date: 2018-01
• Subjects: Tuberculosis (TB) -- Multi-drug resistant tuberculosis (MDR-TB) -- Extensively drug-resistant tuberculosis (XDR-TB) -- Central nervous system (CNS) TB -- Tuberculoma -- Bedaquiline; AFB acid-fast bacilli -- BAL bronchoalveolar lavage -- CNS central nervous system -- CSF cerebrospinal fluid -- CT computerized tomography -- DOT directly observed therapy -- DST drug susceptibility testing -- FDA Food and Drug Administration -- IV intravenous -- LUL left upper lobe -- MDR-TB multidrug-resistant tuberculosis -- MRI magnetic resonance imaging -- TB tuberculosis -- WHO World Health Organization -- XDR-TB extensively drug-resistant tuberculosis; Tuberculosis -- Periodicals; Mycobacterial diseases -- Periodicals; 616.995
• DOI: 10.1016/j.jctube.2017.12.004
• Languages: English
• ISSNs: 2405-5794

Abstract

Abstract: Tuberculosis (TB) is one of the leading causes of death worldwide, particularly in low- and middle-income countries. The global rates and numbers of drug resistant TB are rising. With increasing globalization, the spread of drug-resistant strains of TB has become a mounting global public health concern. We present a case of a young man previously treated for multi-drug resistant (MDR) TB in India who presented with neurological symptoms and central nervous system TB in the United States. His case highlights unique diagnostic and treatment challenges that are likely to become more commonplace with the increase of patients infected with drug-resistant TB and complicated extrapulmonary disease.