Randomized controlled clinical trial on the antiseptic efficacy of polihexanide 0.04% on acute traumatic wounds. Issue 4 (April 2018)

• Record Type: Journal Article
• Authors: Payne, B.; Simmen, H.-P.; Csuka, E.; Hintzpeter, M.; Pahl, S.; Brill, F.H.H.
• Is Part Of: Journal of hospital infection. Volume 98:Issue 4(2018)
• Page Start: 429
• Page End: 432
• Publication Date: 2018-04
• Subjects: Traumatic wounds -- Efficacy -- Polihexanide -- Polyhexamethylene biguanide -- Antiseptic; Cross infection -- Periodicals; Cross infection -- Prevention -- Periodicals; Nosocomial infections -- Periodicals; Nosocomial infections -- Prevention -- Periodicals; Cross Infection -- Periodicals; Cross Infection -- prevention & control -- Periodicals; Infection Control -- Periodicals; Electronic journals; 614.44
• DOI: 10.1016/j.jhin.2017.12.020
• Languages: English
• ISSNs: 0195-6701

Abstract

Summary: Prevention of wound infections is a challenge in clinical practice. The aim of this study was to assess the efficacy of polyhexamethylene biguanide (PHMB, polihexanide) 0.04% on acute traumatic wounds. It was a randomized, double-blind, placebo-controlled prospective trial which included 61 patients. The polihexanide group showed a significant decrease in log10 colony-forming units (cfu) ( P < 0.001) after 60 min treatment in comparison to baseline cfu, whereas the Ringer solution group did not show a significant change in cfu during 60 min treatment. Treatment of polihexanide 0.04% resulted in a significant reduction of bacterial load in acute traumatic wounds.