Honoring 50 Years of Clinical Heart Transplantation in Circulation: In-Depth State-of-the-Art Review. Issue 1 (2nd January 2018)

• Record Type: Journal Article
• Authors: Stehlik, Josef; Kobashigawa, Jon; Hunt, Sharon A.; Reichenspurner, Hermann; Kirklin, James K.
• Is Part Of: Circulation. Volume 137:Issue 1(2018)
• Publication Date: 2018-01-02
• Subjects: heart transplantation -- immunosuppression -- survival; Blood -- Circulation -- Periodicals; Cardiovascular system -- Periodicals; Cardiology -- Periodicals; Heart -- Diseases -- Periodicals; Blood Circulation; Cardiovascular System; Vascular Diseases; 616.1
• DOI: 10.1161/CIRCULATIONAHA.117.029753
• Languages: English
• ISSNs: 0009-7322

Abstract

Abstract : Heart transplantation has become a standard therapy option for advanced heart failure. The translation of heart transplantation from innovative experiments to long-term clinical success has married prescient insights with discipline and organization in the domains of surgical techniques, organ preservation, immunosuppression, organ donation and transplantation logistics, infection control, and long-term graft surveillance. This review explores the key milestones of the past 50 years of heart transplantation and discusses current challenges and promising innovations on the clinical horizon.