Combining cooperativity with sequestration: a novel strategy for discrimination of single nucleotide variants. Issue 26 (12th March 2018)
- Record Type:
- Journal Article
- Title:
- Combining cooperativity with sequestration: a novel strategy for discrimination of single nucleotide variants. Issue 26 (12th March 2018)
- Main Title:
- Combining cooperativity with sequestration: a novel strategy for discrimination of single nucleotide variants
- Authors:
- Hu, Shichao
Li, Na
Liu, Feng - Abstract:
- Abstract : We present a novel single nucleotide variant discrimination strategy combining cooperativity with sequestration to significantly improve the discrimination ability. Abstract : We present a novel strategy for the discrimination of single nucleotide variants (SNVs) by combining cooperativity with sequestration, which displays remarkably high specificity (discrimination factors ranging from 67 to 618 with a median of 194) against 12 model SNVs and can be easily integrated with PCR amplification to detect KRAS G12D mutation.
- Is Part Of:
- Chemical communications. Volume 54:Issue 26(2018)
- Journal:
- Chemical communications
- Issue:
- Volume 54:Issue 26(2018)
- Issue Display:
- Volume 54, Issue 26 (2018)
- Year:
- 2018
- Volume:
- 54
- Issue:
- 26
- Issue Sort Value:
- 2018-0054-0026-0000
- Page Start:
- 3223
- Page End:
- 3226
- Publication Date:
- 2018-03-12
- Subjects:
- Chemistry -- Periodicals
540 - Journal URLs:
- http://pubs.rsc.org/en/journals/journalissues/cc ↗
http://www.rsc.org/ ↗ - DOI:
- 10.1039/c8cc00838h ↗
- Languages:
- English
- ISSNs:
- 1359-7345
- Deposit Type:
- Legaldeposit
- View Content:
- Available online (eLD content is only available in our Reading Rooms) ↗
- Physical Locations:
- British Library DSC - 3139.350000
British Library DSC - BLDSS-3PM
British Library STI - ELD Digital store - Ingest File:
- 6088.xml