In situ photo-patterning of pressure-resistant hydrogel membranes with controlled permeabilities in PEGDA microfluidic channels. Issue 7 (28th February 2018)

• Record Type: Journal Article
• Authors: Decock, Jérémy; Schlenk, Mathias; Salmon, Jean-Baptiste
• Is Part Of: Lab on a chip. Volume 18:Issue 7(2018)
• Page Start: 1075
• Page End: 1083
• Publication Date: 2018-02-28
• Subjects: Miniature electronic equipment -- Periodicals; Combinatorial chemistry -- Periodicals; Biotechnology -- Periodicals; 543.0813
• DOI: 10.1039/c7lc01342f
• Languages: English
• ISSNs: 1473-0197

Abstract

Abstract : We report the fabrication of highly permeable, pressure-resistant, hydrogel membranes in PEGDA channels, by spatially-resolved photo-polymerization. Abstract : We report the fabrication of highly permeable membranes in poly(ethylene glycol) diacrylate (PEGDA) channels, for investigating ultra- or micro-filtration, at the microfluidic scale. More precisely, we used a maskless UV projection setup to photo-pattern PEG-based hydrogel membranes on a large scale (mm–cm), and with a spatial resolution of a few microns. We show that these membranes can withstand trans -membrane pressure drops of up to 7 bar without any leakage, thanks to the strong anchoring of the hydrogel to the channel walls. We also report in situ measurements of the Darcy permeability of these membranes, as a function of the deposited energy during photo-polymerization, and their formulation composition. We show that the use of PEG chains as porogens, as proposed in [Lee et al., Biomacromolecules, 2010, 11, 3316], significantly increases the porosity of the hydrogels, up to Darcy permeabilities of about 1.5 × 10 −16 m 2, while maintaining the strong mechanical stability of the membranes. We finally illustrate the opportunities offered by this technique, by investigating frontal filtration of colloidal dispersions in a straight microfluidic channel.