Chemical constituents from Gueldenstaedtia verna and their anti-inflammatory activity. Issue 10 (19th May 2018)

• Record Type: Journal Article
• Authors: Liu, Xin; Yin, Chengle; Cao, Yue; Zhou, Jinge; Wu, Tao; Cheng, Zhihong
• Is Part Of: Natural product research. Volume 32:Issue 10(2018)
• Page Start: 1145
• Page End: 1149
• Publication Date: 2018-05-19
• Subjects: Gueldenstaedtia verna -- triterpenoid glycoside -- anti-inflammatory -- inhibition of NO production; Natural products -- Periodicals; Natural products -- Research -- Periodicals; Biological Factors -- Periodicals; Biological Products -- Periodicals; 547
• DOI: 10.1080/14786419.2017.1320795
• Languages: English
• ISSNs: 1478-6419

Abstract

Abstract: A new triterpenoid glycoside (1 ) and 15 known compounds (2 –16 ) were isolated from the whole plants of Gueldenstaedtia verna . The new compound (1 ) was identified as complogenin 22- O -β-d -glucopyranoside by extensive spectroscopic techniques including 1D ( 1 H and 13 C) and 2D NMR experiments (HSQC, HMBC and NOESY), HR-DART-MS and chemical methods. Most of the isolates were evaluated for their inhibitory activities on LPS-induced NO production in RAW 264.7 cells. The inhibitory effects of the active compounds, sulphuretin (8 ) and (22 E, 24 S )-5α, 8α-epidioxy-24-methyl-cholesta-6, 9(11), 22-trien-3β-ol (13 ), on the production of pro-inflammatory mediators (including IL-6, IL1β and PGE2 ) were further estimated in vitro by ELISA in RAW 264.7 macrophages. Abstract :