Shikimic Acid Production by Fusarium decemcellulare, An Endophytic Fungus Isolated from Flacourtia inermis Fruits. Issue 1 (2nd January 2018)

• Record Type: Journal Article
• Authors: Qader, M. Mallique; Kumar, N. Savitri; Jayasinghe, Lalith; Fujimoto, Yoshinori
• Is Part Of: Journal of biologically active products from nature. Volume 8:Issue 1(2018)
• Page Start: 43
• Page End: 50
• Publication Date: 2018-01-02
• Subjects: Flacourtia inermis -- Fusarium decemcellulare -- endophytic fungi -- fermentation -- shikimic acid; Natural products -- Periodicals; Biological products -- Periodicals; 660.6
• DOI: 10.1080/22311866.2018.1426494
• Languages: English
• ISSNs: 2231-1866

Abstract

Abstract: Microorganisms have produced many of the most potent agents against bacterial and fungal infections, cancer and high cholesterol etc. Studies on secondary metabolites originating from endophytic fungi isolated in Sri Lanka are relatively less studied. Hence we studied the chemistry and bioactivity of an endophytic fungus Fusarium decemcellulare isolated from the fruits of Flacourtia inermis . A pure culture of fungus was fermented in potato dextrose broth (PDB) for 28 days. The fermentation medium and mycelium was extracted in to ethyl acetate (EtOAc) and methanol (MeOH). These extracts did not show good activity for bioassays against antioxidant, antifungal, α-amylase inhibitory, brine shrimp lethality and phytotoxicity. Chromatographic separation of the EtOAc extract furnished ergosterol while MeOH extract furnished shikimic acid. Isolation of endophytic fungus Fusarium decemcellulare from the fruits of F. inermis and the production of shikimic acid from F. decemcellulare are reported for the first time.