Genome-wide association study of depressive symptoms in the Hispanic Community Health Study/Study of Latinos. (April 2018)

• Record Type: Journal Article
• Authors: Dunn, Erin C.; Sofer, Tamar; Wang, Min-Jung; Soare, Thomas W.; Gallo, Linda C.; Gogarten, Stephanie M.; Kerr, Kathleen F.; Chen, Chia-Yen; Stein, Murray B.; Ursano, Robert J.; Guo, Xiuqing; Jia, Yucheng; Yao, Jie; Rotter, Jerome I.; Argos, Maria; Cai, Jianwen; Perreira, Krista; Wassertheil-Smoller, Sylvia; Smoller, Jordan W.
• Is Part Of: Journal of psychiatric research. Volume 99(2018)
• Page Start: 167
• Page End: 176
• Publication Date: 2018-04
• Subjects: Genetic association study -- Depression -- Depressive symptoms -- Hispanics/Latinos; Psychiatry -- Periodicals; Mental Disorders -- Periodicals; Maladies mentales -- Périodiques; Psychiatry; Electronic journals; Periodicals; 616.89005
• DOI: 10.1016/j.jpsychires.2017.12.010
• Languages: English
• ISSNs: 0022-3956

Abstract

Abstract: Although genome-wide association studies (GWAS) have identified several variants linked to depression, few GWAS of non-European populations have been performed. We conducted a genome-wide analysis of depression in a large, population-based sample of Hispanics/Latinos. Data came from 12, 310 adults in the Hispanic Community Health Study/Study of Latinos (HCHS/SOL). Past-week depressive symptoms were assessed using the 10-item Center for Epidemiological Studies of Depression Scale. Three phenotypes were examined: a total depression score, a total score modified to account for psychiatric medication use, and a score excluding anti-depressant medication users. We estimated heritability due to common variants ( h 2 SNP ), and performed a GWAS of the three phenotypes. Replication was attempted in three independent Hispanic/Latino cohorts. We also performed sex-stratified analyses, analyzed a binary trait indicating probable depression, and conducted three trans-ethnic analyses. The three phenotypes exhibited significant heritability (h 2 SNP = 6.3–6.9%; p = .002) in the total sample. No SNPs were genome-wide significant in analyses of the three phenotypes or the binary indicator of probable depression. In sex-stratified analyses, seven genome-wide significant SNPs (one in females; six in males) were identified, though none were supported through replication. Four out of 24 loci identified in prior GWAS were nominally associated in HCHS/SOL. There was no evidence of overlap in genetic risk factors across ancestry groups, though this may have been due to low power. We conducted the largest GWAS of depression-related phenotypes in Hispanic/Latino adults. Results underscore the genetic complexity of depressive symptoms as a phenotype in this population and suggest the need for much larger samples.