A Behavioral Manipulation Engages Right Frontal Cortex During Aphasia Therapy. (July 2014)

• Record Type: Journal Article
• Authors: Benjamin, Michelle L.; Towler, Stephen; Garcia, Amanda; Park, Hyejin; Sudhyadhom, Atchar; Harnish, Stacy; McGregor, Keith M.; Zlatar, Zvinka; Reilly, Jamie J.; Rosenbek, John C.; Gonzalez Rothi, Leslie J.; Crosson, Bruce
• Is Part Of: Neurorehabilitation & neural repair. Volume 28:Number 6(2014)
• Page Start: 545
• Page End: 553
• Publication Date: 2014-07
• Subjects: aphasia -- magnetic resonance imaging -- fMRI -- rehabilitation -- rehabilitation of speech and language disorders -- neuronal plasticity; Nervous system -- Diseases -- Patients -- Rehabilitation -- Periodicals; Brain damage -- Patients -- Rehabilitation -- Periodicals; Spinal cord -- Wounds and injuries -- Patients -- Rehabilitation -- Periodicals; Nervous system -- Regeneration -- Periodicals; Neuroplasticity -- Periodicals; 616.804305
• DOI: 10.1177/1545968313517754
• Languages: English
• ISSNs: 1545-9683

Abstract

Background . An aphasia treatment was designed to shift laterality from the left to right lateral frontal lobe during word production by initiating word-finding trials with complex left-hand movements. Previous findings indicated successful relateralization. Objective . The current study was designed to ascertain whether the shift was attributable to the left-hand movement. Methods . Using stratified random sampling, 14 subjects were equally divided between Intention (IT) and Control (CT) treatments. CT was identical to IT, except with no left-hand movements. Both treatments trained picture naming (phases 1 and 2) and category-member generation (phase 3), each phase lasting 10 sessions. Functional magnetic resonance imaging of category member generation occurred at pretreatment, posttreatment, and 3-month follow-up. Results . IT shifted lateral frontal activity rightward compared with pretreatment both at posttreatment ( t = −2.602, df = 6, P < .05) and 3-month follow-up ( t = −2.332, df = 5, P < .05), but CT did not. IT and CT yielded similar changes for all picture-naming and category probes. However, IT patients showed gains for untrained category ( t = 3.33, df = 6, P < .01) and picture-naming probes ( t = 3.77, df = 5, P < .01), but CT patients did not. Conclusions . The rightward shift in lateral frontal activity for IT was because of the left-hand movements. IT evoked greater generalization than CT.