Melanogenesis inhibitory pregnane glycosides from Cynanchum atratum. Issue 7 (15th April 2018)

• Record Type: Journal Article
• Authors: Jin, Qinghao; Han, Xiang Hua; Yun, Cheong-Yong; Lee, Chul; Lee, Jin Woo; Lee, Dongho; Lee, Mi Kyeong; Jung, Sang-Hun; Hong, Jin Tae; Kim, Youngsoo; Hwang, Bang Yeon
• Is Part Of: Bioorganic & medicinal chemistry letters. Volume 28:Issue 7(2018)
• Page Start: 1252
• Page End: 1256
• Publication Date: 2018-04-15
• Subjects: Cynanchum atratum -- Asclepiadaceae -- Pregnane glycosides -- α-MSH -- Melanogenesis inhibitor; Bioorganic chemistry -- Periodicals; Pharmaceutical chemistry -- Periodicals; 572
• DOI: 10.1016/j.bmcl.2018.01.004
• Languages: English
• ISSNs: 0960-894X

Abstract

Graphical abstract: Abstract: Bioassay-guided fractionation of the methanolic extract from the roots of Cynanchum atratum has resulted in the isolation of three new pregnane glycosides (1 –3 ) along with four known compounds (4 –7 ). Their structures were identified by analysis of the spectroscopic data including extensive 2D NMR. All of the isolates were evaluated for their potential to inhibit the melanin production in α-melanocyte stimulating hormone (α-MSH)-activated B16 melanoma cells. Of these, compounds4 –7 dose-dependently inhibited the melanin production with the IC50 values ranging from 4 μM to 33 μM.