Prognostic significance of circulating soluble programmed death ligand-1 in patients with solid tumors: A meta-analysis. Issue 3 (January 2018)

• Record Type: Journal Article
• Authors: Wei, Wei; Xu, Bin; Wang, Yan; Wu, Chen; Jiang, Jingting; Wu, Changping
• Other Names: Shankar. Esaki M. section editor.
• Is Part Of: Medicine. Volume 97:Issue 3(2018)
• Publication Date: 2018-01
• Subjects: prognosis -- solid tumor -- soluble programmed death ligand-1; Medicine -- Periodicals; Medicine -- Periodicals; Médecine -- Périodiques; Geneeskunde; Medicine; Periodicals; Periodicals; 610.5
• DOI: 10.1097/MD.0000000000009617
• Languages: English
• ISSNs: 0025-7974

Abstract

Abstract: Background: The prognostic significance of circulating soluble programmed death ligand-1 (sPD-L1) in patients with solid tumors remains unclear. We performed a meta-analysis to address this issue. Methods: Several electronic databases were searched from January 1970 to May 2017. The hazard ratios (HRs) and 95% confidence interval (95% CI) were calculated to determine the relationship between the level of soluble PD-L1 in peripheral blood and patient overall survival. Results: A total of 1040 patients with solid tumors from 8 eligible studies were included in the present meta-analysis. The pooled HR suggested that a high level of soluble PD-L1 (sPD-L1) in peripheral blood was significantly correlated with a worse overall survival (HR = 2.26, 95% 1.83–2.80, Z = 7.51, P < .001). Conclusion: The present meta-analysis demonstrated that a high level of soluble PD-L1 in peripheral blood significantly predicts poor prognosis in patients with solid tumors, suggesting that high level of sPD-L1 may serve as a predictive biomarker for poor prognosis.